Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a coordinated attack targeting an underground arms cache in Syrian territory operated by the IS group, according to the British defence ministry.
The location, located using reconnaissance, was assessed as storing arms and explosives, the statement said, and was located in hills just above the historic site of Palmyra in Syria's central region.
"Our aircraft utilized laser-guided Paveway IV weapons to hit a series of approach shafts providing entry to the site... preliminary assessments indicate the strike was effective," officials stated.
There was no evidence of any civilian impact in the attack conducted Saturday night and each participating jet returned to base without incident, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
Daesh - also known as ISIS - enforced militant control over parts of Iraq and Syria prior to its 2019 collapse.
"This action underscores the UK's leading role, and commitment to work closely with allied nations, to eliminate any resurgence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary the minister said.
British military aircraft have performed patrols over Syrian airspace to "deter any attempted resurgence" of the group after its routing at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I must thank all the members of our armed forces involved in this strike for their skill and their bravery," he added. "They were part of thousands of UK service members deployed over the holidays. This mission, to remove terrorist threats who pose a risk to our safety, shows how UK forces are ready to step up, throughout the year, keeping Britain secure domestically and powerful internationally."
During December, the US military carried out what it described as a "massive strike" against Daesh sites in the country, following an attack claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The United Nations estimates Islamic State still maintains roughly 5-7 thousand combatants in Iraq and Syria.